Crash Course Immunology — Part 1 of Cancer Immunotherapy Series

Note: This is just part 1 of my article series on cancer immunotherapy and covers basic immunology concepts that you might need to know to better understand the remaining articles on specific methodologies for cancer immunology.
This article does assume that you have some understanding of topics like transcription, translation, mitosis and meiosis, the chromosomal theory of inheritance, and cell biology. If you aren’t familiar with these, I’ve linked some resources for different topics throughout the article as they come up, so feel free to read those, understand the topic, and then come back to continue reading the article!

Photo by UCSF Health

Let’s Start From The Top


How Is It Different Than Your Normal Age, and Why Is It Important?

Photo by Cristina Gottardi on Unsplash

Everyone knows that as a person gets older, their health slowly gets worse and worse. From a young age, we’ve seen grandparents and other “old” people suffer from different diseases, frailty, poor eyesight, and a host of other problems.

But what some people might not realize is that it’s not as simple as a linear function where everyone in the world has the same health deterioration at the same age. …

Photo Source: Pinterest

The Exciting Science Behind Generating A Map of the Brain

Humanity has come a long way since we first evolved from our ape ancestors. It started slow (extremely slow), with figuring out how to light a fire and make tools using stones, but quickly picked up to the point where, about 200,000 years later, we can manipulate life at the smallest orders of molecules, launch people into space, and even manipulate atoms to meet our desires.

A CRISPR-mediated Coronavirus Treatment and Prevention Strategy

In mid-February, this year, Timothy Abbott, PhD Candidate at Stanford University’s Bioengineering Department, and Dr Marie La Russa, a research scientist working at Dr Stanley Qi’s lab at Stanford, found a way to create a therapeutic agent to prevent all forms of coronavirus.

In this breakthrough research, Abbott was using an approach called PAC-MAN (Prophylactic Antiviral CRISPR in huMAN cells) to attack RNA viruses, which includes the coronavirus family, and degrade their genetic code. …

Transposable Elements and Lifespan Reduction

Source: Dribbble

Survival of the fittest.

The backbone of the Darwinian theory of evolution that we are all familiar with. If a trait makes a certain animal more likely to survive (among other often smaller factors), then that animal will have a higher reproduction rate, leading to more animals in the next generation possessing the advantageous trait. As this cycle continues, the trait eventually becomes common across all members of the species.

Using Yamanaka Factors to Reverse Epigenetic Noise and Regenerate Aged Tissues

In 2006, Dr. Shinya Yamanaka, a Japanese stem cell researcher, published his paper on induced pluripotent stem cells, and it changed the medical world. Dr. Yamanaka had found a way to convert a mature skin cell into a stem cell by injecting just a few genes. And for this, Dr. Yamanaka received the Nobel Prize in Physiology or Medicine in 2012, sharing it with another Sir John B. Gurdon, who found another method of inducing pluripotency.

A Peek Into the Vaccine Development Industry

If you’re anything like me, you’re tired of being in lockdown because of the coronavirus, or SARS-CoV-2.

You’re tired of having to put on a mask every time you go to get groceries.

You’re tired of maintaining a 2-meter distance from everyone, acting like you are repulsed by everyone else.

You’re tired of being bombarded by bad news surrounding the outbreak, and the number of deaths it has caused.

A Research Proposal To Treat Alzheimer’s Disease Using AAV-Mediated Microglial TREM2 Gene Editing

I’m sure you’ve heard of Alzheimer’s Disease (AD). It’s a neurodegenerative disorder most commonly characterized by dementia, loss of judgement, and overall, the loss of cognitive function. It affects over 5.8 million Americans or 11% of all Americans over the age of 65. And in 2018 alone, Alzheimer’s accounted for 122, 019 deaths, making it the sixth leading cause of death in America and the fifth leading cause of death among Americans above 65.

So, as you might guess, lots and lots of research has been done to find treatments and cures for the disease, ranging from small drug molecules…

The most recent breakthrough in age reversal in rats

Everyone (or at least everyone that isn’t a child) hates getting older.

I mean why wouldn’t we? Every single year we add on to our age is like taking one more step towards a cliff. Sooner or later, you’re gonna reach the cliff, and the next step you take will be your last.

Except, we’re blindfolded as we take these steps, and we don’t have a clue how far from the cliff we start. For all we know, the next step could be our last.

But some people might be able to grab the cliff and hold on after they…

The Reasons You Age and Eventually Die

The Depressing Truth

Since childhood, every single one of us is aware that our time on this planet is running out. The same aging process that we celebrate early in our life with birthdays and parties, will be the cause of our demise in our later life.

And this fact has shaped our entire society and the way we live. For example, when we’re children, the chances of us dying because of age are nonexistent. So, we frolic around with no worries.

As teenagers, we become mature and aware of the approaching end to life, so we study and prepare for our adult…

Akshaj Darbar

18 y/o innovator working on reversing ageing and researching cancer vaccines.

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