Using Base Editing to Treat Alzheimer’s Disease

A Research Proposal To Treat Alzheimer’s Disease Using AAV-Mediated Microglial TREM2 Gene Editing

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“The reality of this disease is that there is no remission, there’s no stopping it, there’s no slowing it down, there’s no cure, and there are no survivors”
- Suzanne Tackett, Alzheimer’s patient

Why Does Alzheimer’s Develop?

Amyloid Cascade Hypothesis

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Beta-Amyloid Peptide
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The γ-secretase complex, with presenilin-1, highlighted in orange

Sporadic Alzheimer’s Disease

Microglia Dysfunction

TREM2 Function

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The process of phagocytosis, and how it contributes to immunity

TREM2 Mutations and Effects

The Proposal

Base Editing

Adeno-Associated Virus Vectors

Expected Results

Key Takeaways

18 y/o innovator working on reversing ageing and researching cancer vaccines.

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